4 edition of Growth hormone and insulin-like growth factor I in human and experimental diabetes found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Allan Flyvbjerg, Hans Ørskov, and George Alberti.|
|Contributions||Flyvbjerg, Allan., Ørskov, Hans., Alberti, George.|
|LC Classifications||RC660 .G77 1993|
|The Physical Object|
|Pagination||xiii, 322 p. :|
|Number of Pages||322|
|LC Control Number||92049208|
Growth hormone (GH) and related growth factors, in particular, insulin-like growth factor I (IGF I) are thought to control linear growth in phases of acceleration. Since growth acceleration occurs predominantly during or shortly before puberty, the sex hormones, estrogen and testosterone, may also have an important role. The regulation of DNA replication by growth hormone and the production of somatomedin C/insulin-like growth factor I (SM-C/IGF-I) and insulin by fetal rat islets in culture has been studied. Islets were cultured for 3 days in medium containing or mM glucose, various concentrations of fetal calf serum (FCS), and ng/ml human growth hormone (GH).
See the article "Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH" in volume on page In PNAS, Schally et al. (1) demonstrate the in vivo antitumor activity of the recently developed growth hormone-releasing hormone (GHRH) agonist MR The effects of recombinant human growth hormone (GH, 1 µg/ml) and insulin-like growth factor I (IGF-I, ng/ml) on the production of insulin and glucagon by human fetal islet-like cell clusters (ICCs) were studied in tissue culture. ICCs were derived after collagenase digestion and culture of pancreases from 16 fetuses (mean gestational age wk).
Growth hormone and cortisol secretion were studied in 25 patients with insulin‐dependent diabetes before (Study 1) and 2 weeks after improved glucoregulation (Study 2). Blood samples for serum growth. Objective. Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure among children and is often progressive despite maximal medical therapy. Heart failure is characterized by a number of neurohormonal abnormalities, including derangements in the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) signaling axis. Decreased serum levels of GH, which acts on cardiac.
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Insulin-like growth factor-1 (IGF-1 or IGF) is a hormone your liver makes. One of its main jobs is to tell your bones and muscles to grow. It’s in the same family as the hormone insulin and acts.
Insulin-like growth factor-1 (IGF-1 or IGF) is a hormone your liver makes. One of its main jobs is to tell your bones and muscles to grow. It’s in the same family as the hormone insulin and acts Author: Linda Rath.
ISBN: OCLC Number: Description: xiii, pages: illustrations ; 24 cm: Contents: Growth hormone and insulin-like growth factor I: basic aspects / W. Kiess [and others] --Alterations in the growth hormone/insulin-like growth factor I axis in human and experimental diabetes: differences and similarities / S.M Marshall and K.G.M.M.
Alberti --Insulin-like. Growth hormone concentrations in people with diabetes are 2 to 3 times higher than in people who don’t have diabetes.
Abnormal levels of IGF and growth hormones may also play a role in the Author: Ann Pietrangelo. Recent investigations have suggested a role for growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the pathogenesis of experimental renal growth and scarring A role for these hormones/growth factors has also been postulated in the development and progression of diabetic nephropathy.4 We have explored their contribution to Cited by: Hansen AaP: Serum growth hormone patterns in juvenile diabetes.
Dan Med Bull(suppl 1) Flyvbjerg A: The role of insulin-like growth factor I in initial renal hypertrophy in experimental diabetes, in Flyvbjerg A, Orskov H, Alberti KGMM (eds): Growth Hormone and Insulin-Like Growth Factor I in Human and Experimental Diabetes. Insulin-like growth factor I for the treatment of osteoporosis Overview Murine studies Human studies of insulin-like growth factor I and bone mineral density Limitations to the clinical use of recombinant human insulin-like growth factor I Summary Acknowledgments References Further reading Through the action of insulin-like growth factor-1 (IGF-1), human growth hormone can help with the management of diabetes.
IGF-1, whose production is stimulated by the hormone, is said to produce similar action as insulin. It improves the absorption of glucose from the bloodstream. Cusi K, DeFronzo R. Recombinant human insulin-like growth factor I treatment for 1 week improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance.
J Clin Endocrinol Metab. ; – The role of growth hormone (GH) and insulin-like growth factor-I (IGF-I) change through early childhood. Whereas poor growth is a later presenting feature, infants with isolated GH deficiency have a normal birth weight and length, and often present with hypoglycemia.
In vitro regulation of growth hormone release from ovine pituitary cells during fetal and neonatal development: effects of growth hormone-releasing factor, somatostatin, and insulin-like growth factor-I.
Endocrinology ;– Premera Blue Cross: “Increlex (mecasermin); Recombinant Human Insulin-Like Growth Factor” Growth Hormone and IGF Research: “Therapy with recombinant human.
Jennifer C. Woo, Gregg A. Dean, Alora Lavoy, Ross Clark, Peter F. Moore, Investigation of Recombinant Human Insulin-Like Growth Factor Type I in Thymus Regeneration in the Acute Stage of Experimental FIV Infection in Juvenile Cats, AIDS Research and Human Retroviruses, /, 15, 15, (), ().
Conway GS, Jacobs HS, Holly JM, et al. Effects of luteinizing hormone, insulin, insulin-like growth factor-I and insulin-like growth factor small binding protein 1 in the polycystic ovary syndrome. Clin Endocrinol (Oxf) ; – There was a low serum insulin-like growth factor-1 (IGF-1) of 60 ng/ml (normal age-corrected range, 97– ng/ml) and a very low insulin-like growth factor-binding protein 3 (IGFBP-3) level of mg/l (normal age-corrected range, – mg/l) were found, together with low basal growth hormone levels ( ng/ml) and no clonidine.
The growth hormone (GH)-insulin-like growth factor (IGF) axis and insulin are major anabolic effectors in promoting weight gain and linear growth. These two anabolic systems are interlinked at many levels, thus abnormalities in one of these systems effect the other causing disordered metabolic homeo.
IGF1/GH Axis-The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1, or sometimes with a Roman numeral as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH).
IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. Book Review; Published: February Growth hormone and insulin-like growth factor I in human and experimental diabetes]Flyvbjerg A, Ørskov H, Alberti KGMM (eds) John Wiley & Sons, Chichester:pp.
ISBN The term insulin-like growth factor is derived from the ability of high concentrations of these factors to mimic the action of insulin, although their primary action is to stimulate growth. Serum IGF-1 concentrations increase progressively with age in children, with an accelerated increase at the time of the pubertal growth spurt.
Human Placental Growth Hormone, Insulin-Like Growth Factor I and -II, and Insulin Requirements during Pregnancy in Type 1 Diabetes A recent study in nonpregnant transgenic mice revealed that hPGH causes insulin resistance at levels somewhat above human third trimester levels.
Diabetes in pregnancy may lead to macrosomia in the newborn, but. Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults.
IGF-1 is a protein that in humans is encoded by the IGF1 gene. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges.Janssen JA, Stolk RP, Pols HA, et al. Serum free and total insulin-like growth factor-I, insulin-like growth factor binding protein-1 and insulin-like growth factor binding protein-3 Levels in healthy elderly individuals: relation to self-reported quality of health and disability.
Gerontology ; 44(5): –80 PubMed CrossRef Google Scholar.Growth hormone (GH), brain development and neural stem cells. Pediatr Endocrinol Rev. ; – Medline Google Scholar; 6. Aberg ND, Brywe KG, Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain.
Sci World J.